Regeneration and Repair of the Exocrine Pancreas

Hedgehog signaling is required for effective regeneration of exocrine pancreas.

Although both endocrine and the exocrine pancreas display a significant capacity for tissue regeneration and renewal, the existence of progenitor cells in the adult pancreas remains uncertain. Using a model of cerulein-mediated injury and repair, we demonstrate that mature exocrine cells, defined by expression of an Elastase1 promoter, actively contribute to regenerating pancreatic epithelium t...

The exocrine pancreas

This seminar text reviews various forms of enzyme supplementation used clinically in digestive and absorption disorders. Enzyme supplementation plays an integral role in the management of various digestive disorders, particularly with regard to exocrine pancreatic insufficiency. However, application of enzymes may also be beneficial for other conditions associated with poor digestion including ...

Exocrine pancreas cancer

The Exocrine Pancreas: Normal and Abnormal Functions

The selection of topics, caliber of participants and content of the proceedings of this symposium reflect the high standards of the Ciba Foundation for scientific excellence. The broad range of topics covered by international authorities, together with the discussion, has been extremely well edited and the material is compiled in a logical sequence. The section on ultrastructure and histochemis...

Diabetes mellitus and the exocrine pancreas.

Diabetes and carbohydrate intolerance can occur in pancreatitis. Although one-half of patients with acute pancreatitis will have some evidence of glucose intolerance during their acute illness, few will require insulin administration on either a short- or long-term basis. The diabetes seen in acute pancreatitis is likely due to a combination of factors, including alerted insulin secretion, incr...